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KMID : 0923620090090040122
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Immune Network
2009 Volume.9 No. 4 p.122 ~ p.126
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Regulation of Tumor Immune Surveillance and Tumor Immune Subversion by TGF-β
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Park Hye-Young
Lalage M Wakefield
Mamura Mizuko
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Abstract
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Transforming growth factor-β (TGF-β) is a highly pleiotropic cytokine playing pivotal roles in immune regulation. TGF-β facilitates tumor cell survival and metastasis by targeting multiple cellular components. Focusing on its immunosuppressive functions, TGF-β antagonists have been employed for cancer treatment to enhance tumor immunity. TGF-β antagonists exert anti-tumor effects through #1 activating effector cells such as NK cells and cytotoxic CD8+ T cells (CTLs), #2 inhibiting regulatory/suppressor cell populations, #3 making tumor cells visible to immune cells, #4 inhibiting the production of tumor growth factors. This review focuses on the effect of TGF-β on T cells, which are differentiated into effector T cells or newly identified tumor-supporting T cells.
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KEYWORD
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transforming growth factor-β (TGF-β), primary tumor, metastasis, CD8＋T cells, IL-17
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